![]() ![]() IRT became the main system in charge of managing patient randomization and drug allocation strategies (see here), hence had a spreading impact on guaranteeing the compliance to blinding requirements. In parallel to the growing popularity – and complexity – of RCTs, the use of Interactive Response Technology (IRT) platforms have sored too. Randomized Controlled Trials (RCTs) have steadily become the new standard in the clinical world as their design support bias risk reduction. In fact, the international standards defined in the ICH guideline on Statistical Principles for Clinical Trials (E9) states that “the most important techniques to avoid bias in clinical trials are randomization and blinding.” What to do to avoid introducing bias
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